Search results for "Inosine triphosphate"

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Clinical and Morphologic Predictors of Outcome in a Multicenter Cohort of ITP Patients Treated with Trombopoietin Analogues

2018

Abstract Background: The role of bone marrow response in patients with immune thrombocytopenia (ITP) has gained paramount importance since the last 10 years, with the demonstrations that marrow megakaryocytes (MGK) are unable to properly compensate platelets peripheral destruction. TPO receptor agonists (TPOa), namely romiplostim (ROMI) and eltrombopag (EPAG), by stimulating megakaryopoiesis are able to induce a response in 74% to 94% of cases in clinical trials. However, real world use of these drugs has shown frequent changes in individual dose requirement, the possibility of treatment discontinuation, and their effectiveness outside registered indications; moreover, nothing is known abou…

medicine.medical_specialtyRomiplostimbusiness.industryImmunologyEltrombopagAzathioprineCell BiologyHematologymedicine.diseaseBiochemistryInosine triphosphatechemistry.chemical_compoundchemistryDysplasiaInternal medicineCohortmedicineMiddle-aged adultbusinessAdverse effectmedicine.drugBlood

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